...  dependence that can be prescribed in a doctor’s office. This change will provide more patients the opportunity to access treatment. 5. What are some possible side effects of Subutex and Suboxone? (This is NOT a complete list of side effects reported with Suboxone and Subutex. Refer to the package insert for a more complete list of side effects.) The most common reported side effect of Subutex and Suboxone include: cold or flu-like symptoms headaches sweating sleeping difficulties nausea mood swings. Like other opioids Subutex and Suboxone have been associated with respiratory depression (difficulty breathing) especially when combined with other depressants. 6. Are patients able to take home supplies of these medicines? Yes. Subutex and Suboxone are less tightly controlled than methadone because they have a lower potential for abuse and are less dangerous in an overdose. As patients progress on therapy, their doctor may write a prescription for a take-home supply of the ...